Paramount said the movie, one of the Viacom unit's biggest franchises, remained on schedule to open on July 27, 2018 despite the setback.
Cruise has carved a career as one of Hollywood's top-earning and longest-running action stars, much of it built on his reputation for doing his own stunts, including swinging around a Dubai skyscraper and hanging off the outside of a cargo plane as takes off.
"Mission: Impossible 6" director Christopher McQuarrie told Britain's Empire magazine in an interview posted on Wednesday that Cruise was in "very good spirits" after his injury.
McQuarrie said Cruise was performing a stunt over numerous takes where he was meant to hit the wall of the building hard, climb onto the roof and sink to his knees. On his fourth try, McQuarrie said Cruise "hit the building at a slightly different angle" and broke his right ankle.
"Tom wants to thank you all for your concern and support and can't wait to share the film with everyone next summer."